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Enhancing molecular bonds to protect health!

Keywords: glycan, antibody, molecular recognition, multivalent effect, detection reagent

The proverb "When three people gather, the wisdom of Monju" is often heard in our daily lives. Did you know that the power of groups exists even at the molecular level? Glycans facilitate intercellular communication by binding to glycan receptors, but individual glycans have only weak binding strength. However, when multiple glycans come together, their effect far exceeds simple addition, sometimes exhibiting astonishing powers that can be hundreds to hundreds of thousands of times greater. This is called the "multivalency effect." The characteristic of our research is to artificially replicate and further enhance this clever mechanism found in nature. We design artificial molecules that accumulate various molecules, such as glycans and next-generation antibodies, and investigate their interactions in detail. By effectively utilizing the power of molecular cooperation, we hope to contribute to the future of medicine.

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